Description

6-((tert-Butoxycarbonyl)Amino)-2-Oxaspiro[3.3]Heptane-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel, conformationally constrained bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) with spirocyclic architectures.
• Protease Inhibitor Development: Used in research for creating constrained peptidomimetics targeting various protease enzymes.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile scaffold for constructing compound libraries to explore new chemical space and improve drug-like properties.
• Bioconjugation & Linker Chemistry: The carboxylic acid and Boc-protected amine functionalities allow for selective conjugation in prodrug and linker design.
• Academic & Institutional Research: Employed in universities and research institutes for studying structure-activity relationships (SAR) and molecular recognition.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	6-((tert-Butoxycarbonyl)Amino)-2-Oxaspiro[3.3]Heptane-6-Carboxylic Acid
CAS No.	1823515-64-5
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	6-((Boc)Amino)-2-oxaspiro[3.3]heptane-6-carboxylic acid; 2-Oxaspiro[3.3]heptane-6-carboxylic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-; 6-(tert-Butoxycarbonylamino)-2-oxaspiro[3.3]heptane-6-carboxylic Acid; Boc-6-Amino-2-oxaspiro[3.3]heptane-6-carboxylic Acid; 6-N-Boc-amino-2-oxaspiro[3.3]heptane-6-carboxylic Acid; (6-((tert-Butoxycarbonyl)amino)-2-oxaspiro[3.3]heptan-6-yl)formic acid; CAS 1823515-64-5
EINECS	Contact for details

Quality Control

Our 6-((tert-Butoxycarbonyl)Amino)-2-Oxaspiro[3.3]Heptane-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.