Description

5-Benzyl 2-tert-Butyl 8-(Hydroxymethyl)-2,5-Diazaspiro[3.5]Nonane-2,5-Dicarboxylate is a high-value, protected spirocyclic diamine derivative used as a sophisticated building block in advanced organic synthesis. This compound is critical for medicinal chemistry research, enabling the rapid construction of complex molecular architectures with precise stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral scaffold for synthesizing potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space due to its constrained spirocyclic structure.
• Peptidomimetic Synthesis: Serves as a rigid, non-natural amino acid analog for creating conformationally restricted peptides with enhanced metabolic stability.
• Ligand and Catalyst Development: Employed in the preparation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	5-Benzyl 2-tert-Butyl 8-(Hydroxymethyl)-2,5-Diazaspiro[3.5]Nonane-2,5-Dicarboxylate
CAS No.	1823417-97-5
Molecular Formula	C21H30N2O5
Molecular Weight	390.48 g/mol
Synonyms	2,5-Diazaspiro[3.5]nonane-2,5-dicarboxylic acid, 8-(hydroxymethyl)-, 5-benzyl 2-(1,1-dimethylethyl) ester; 8-(Hydroxymethyl)-2,5-diazaspiro[3.5]nonane-2,5-dicarboxylic acid 5-benzyl 2-tert-butyl ester; tert-Butyl 8-(hydroxymethyl)-5-(phenylmethyl)-2,5-diazaspiro[3.5]nonane-2-carboxylate; 5-Benzyl 2-tert-butyl 8-(hydroxymethyl)-2,5-diazaspiro[3.5]nonane-2,5-dicarboxylate; Spirocyclic Diamine Ester Derivative; Bn-Protected Spirocyclic Intermediate
EINECS	Contact for details

Quality Control

Our 5-Benzyl 2-tert-Butyl 8-(Hydroxymethyl)-2,5-Diazaspiro[3.5]Nonane-2,5-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis where applicable, to ensure it meets the stringent requirements of pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.