Description

tert-Butyl 8-(2-Aminoethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for constructing novel, complex molecular architectures. It is primarily utilized by pharmaceutical and biotechnology companies engaged in the synthesis of new chemical entities (NCEs), particularly for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic and aminoethyl motifs make it a valuable linker or component in the design of heterobifunctional degraders.
• CNS Drug Discovery: The structural features are conducive to developing compounds targeting neurological disorders.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog in peptide-based drug design.
• Chemical Biology Probes: Used to create tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 8-(2-Aminoethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1823417-57-7
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]oct-8-yl]ethanamine; 8-(2-Aminoethyl)-2-[(2-methylpropan-2-yl)oxycarbonyl]-5-oxa-2-azaspiro[3.4]octane; tert-Butyl 8-(2-aminoethyl)-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 5-Oxa-2-azaspiro[3.4]octane-2-carboxylic acid, 8-(2-aminoethyl)-, 1,1-dimethylethyl ester; BOC-5-Oxa-2-azaspiro[3.4]octane-8-ethylamine; (8-(2-Aminoethyl)-5-oxa-2-azaspiro[3.4]oct-2-yl)(tert-butyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-(2-Aminoethyl)-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.