Description

tert-Butyl 3-(Hydroxymethyl)-2-Isopropyl-4,5-Dihydro-2H-Pyrazolo[3,4-C]Pyridine-6(7H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused pyrazolopyridine structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated heterocyclic scaffolds. Pharmaceutical R&D and process chemistry teams need this material for developing next-generation drug candidates, leveraging its functional groups for further chemical elaboration.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug molecules, especially in medicinal chemistry programs.
• API Synthesis: Serves as a crucial building block for constructing complex Active Pharmaceutical Ingredients (APIs) with potential therapeutic applications.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive compounds.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs engaged in custom synthesis and development services for pharmaceutical clients.
• Heterocyclic Chemistry: Valued in academic and industrial research focused on the synthesis and properties of novel nitrogen-containing heterocycles.

Basic Information

Product Name	tert-Butyl 3-(Hydroxymethyl)-2-Isopropyl-4,5-Dihydro-2H-Pyrazolo[3,4-C]Pyridine-6(7H)-Carboxylate
CAS No.	1823389-31-6
Molecular Formula	C16H27N3O3
Molecular Weight	309.41 g/mol
Synonyms	6-tert-Butoxycarbonyl-2-isopropyl-3-hydroxymethyl-4,5,6,7-tetrahydropyrazolo[3,4-c]pyridine; 2H-Pyrazolo[3,4-c]pyridine-6(7H)-carboxylic acid, 4,5-dihydro-3-(hydroxymethyl)-2-(1-methylethyl)-, 1,1-dimethylethyl ester; tert-Butyl 3-(hydroxymethyl)-2-(propan-2-yl)-4,7-dihydro-2H-pyrazolo[3,4-c]pyridine-6-carboxylate; 1823389-31-6; TBHIPPC; Pyrazolopyridine Derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Hydroxymethyl)-2-Isopropyl-4,5-Dihydro-2H-Pyrazolo[3,4-C]Pyridine-6(7H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, available upon request. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical development and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.