Description

4'-Methyl-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily targeted at pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic core.
• API Synthesis: Employed in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), especially for targeted therapies.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes to study biological pathways and protein functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	4'-Methyl-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	1823338-03-9
Molecular Formula	C12H11NO
Molecular Weight	185.22 g/mol
Synonyms	4'-Methylspiro[cyclopropane-1,3'-indolin]-2'-one; 1'H-Spiro[cyclopropane-1,3'-indole]-2'-one, 4'-methyl-; 4'-Methyl-1'H-spiro[cyclopropane-1,3'-indol]-2'(3'H)-one; 4-Methylspiro[cyclopropane-1,3'-indolin]-2'-one; Spiro[cyclopropane-1,3'-indole]-2'-one, 4'-methyl-; 1823338-03-9
EINECS	Contact for details

Quality Control

Our 4'-Methyl-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.