Description

tert-Butyl 5-Hydroxy-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• API Development: Serves as a building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.
• Library Synthesis: Used to generate focused compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	tert-Butyl 5-Hydroxy-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS No.	1823272-51-0
Molecular Formula	C17H22N2O4
Molecular Weight	318.37 g/mol
Synonyms	1'-Boc-5-Hydroxy-2-oxospiro[indoline-3,4'-piperidine]; 5-Hydroxy-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5-hydroxy-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 1'-tert-Butoxycarbonyl-5-hydroxy-2-oxospiro[indoline-3,4'-piperidine]; 5-Hydroxy-1'-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidin]-2-one; Spiro[indoline-3,4'-piperidine]-1'-carboxylic acid, 5-hydroxy-2-oxo-, 1,1-dimethylethyl ester; 1823272-51-0; 1'-Boc-5-hydroxy-spiro[indoline-3,4'-piperidin]-2-one
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Hydroxy-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.