Description

tert-Butyl 4-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate (Wx101854) is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and oxazolidinone-like structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential therapeutic applications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug molecules, particularly those targeting the central nervous system (CNS) and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained spirocyclic scaffold.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale synthesis for the production of candidate drugs during clinical trials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical market.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.
• Precursor for Bioactive Molecules: Acts as a precursor for compounds with potential pharmacological activity, including protease inhibitors or receptor modulators.

Basic Information

Product Name	tert-Butyl 4-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate (Wx101854)
CAS No.	1822505-03-2
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	7-Boc-4-hydroxy-1-oxa-7-azaspiro[4.4]nonane; tert-Butyl 4-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate; 1-Oxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester; 4-Hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylic acid tert-butyl ester; WX-101854; Wx101854; Boc-protected spirocyclic amino alcohol.
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.