Description

Racemic-(5S,9S)-tert-Butyl 7-Benzyl-9-(Hydroxymethyl)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate (Wx101609) is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and diazepane scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors working on central nervous system (CNS) targets, receptor modulators, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potential drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the 2,7-diazaspiro[4.4]nonane core.
• Process Chemistry Development: Serves as a standard for developing and scaling up robust, cost-effective synthetic routes for complex heterocycles under GMP-like conditions.
• Library Synthesis: Employed for generating focused screening libraries of spirocyclic compounds for high-throughput screening (HTS) against novel biological targets.
• Chemical Biology Probes: Can be utilized to develop tool compounds and probes for studying enzyme function or receptor interactions in biological systems.

Basic Information

Product Name	Racemic-(5S,9S)-tert-Butyl 7-Benzyl-9-(Hydroxymethyl)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate (Wx101609)
CAS No.	1821776-63-9
Molecular Formula	C20H30N2O3
Molecular Weight	346.47 g/mol
Synonyms	tert-Butyl 7-benzyl-9-(hydroxymethyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate; 2,7-Diazaspiro[4.4]nonane-2-carboxylic acid, 7-benzyl-9-(hydroxymethyl)-, 1,1-dimethylethyl ester, (5S,9S)-rel-; WX-101609; Wx101609; 7-Benzyl-9-(hydroxymethyl)-2,7-diazaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; (rel)-(5S,9S)-tert-Butyl 7-benzyl-9-(hydroxymethyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate
EINECS	Contact for details

Quality Control

Our Racemic-(5S,9S)-tert-Butyl 7-Benzyl-9-(Hydroxymethyl)-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support our clients with full analytical data including HPLC, NMR, and MS to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.