Description

Azide-Peg12-Tos is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a tosylate leaving group, separated by a 12-unit PEG spacer. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific coupling of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require precise and stable crosslinking for creating antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized nanoparticles.

Application

• Bioconjugation and ADC Development: Site-specific coupling of cytotoxic drugs to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry (CuAAC).
• PEGylation Reagent: Introduction of a hydrophilic, flexible PEG spacer to therapeutic proteins, peptides, or small molecules to improve pharmacokinetics and reduce immunogenicity.
• Surface Functionalization: Modification of nanoparticles, quantum dots, or biosensor surfaces with azide groups for subsequent bio-orthogonal labeling.
• Polymer Chemistry: Used as a macromolecular initiator or chain transfer agent in the synthesis of functional, telechelic polymers and block copolymers.
• Diagnostic Probe Synthesis: Construction of imaging probes and diagnostic agents by conjugating targeting ligands with reporter molecules (e.g., fluorophores, radiolabels).
• Hydrogel Formation: Crosslinking agent for creating biocompatible hydrogels with tailored mechanical properties for drug delivery and tissue engineering.

Basic Information

Product Name	Azide-Peg12-Tos
CAS No.	1821464-56-5
Molecular Formula	C33H67N3O15S
Molecular Weight	777.96 g/mol
Synonyms	Azido-PEG12-Tosylate; 1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-38-yl 4-methylbenzenesulfonate; Tosyl-PEG12-Azide; N3-PEG12-OTs; PEG12 Azide Tosylate; Azido-Polyethylene Glycol12-Tosylate; Heterobifunctional PEG Linker, Azide/Tosylate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized by NMR, HPLC, and mass spectrometry to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the tosylate group. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide, NMR)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.