Description

N3-Peg12-Oh is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group at one terminus and a hydroxyl group at the other. This compound is a critical reagent in bioconjugation and click chemistry, enabling the precise and efficient coupling of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in pharmaceuticals, diagnostics, and advanced materials development who require reliable, high-purity linkers for constructing complex molecular architectures.

Application

• Bioconjugation Reagent: Used to link azide-modified biomolecules (e.g., antibodies, peptides, oligonucleotides) to hydroxyl-presenting surfaces or polymers via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• PEGylation Agent: Serves as a spacer to introduce hydrophilic PEG chains onto drug molecules or nanoparticles, improving solubility, stability, and pharmacokinetics.
• Polymer Chemistry: Acts as a functional initiator or monomer in the synthesis of block copolymers and functionalized hydrogels with clickable handles.
• Surface Functionalization: Enables the creation of azide-terminated self-assembled monolayers (SAMs) on hydroxyl-rich substrates like glass or metal oxides for biosensor development.
• Diagnostic Probe Synthesis: Facilitates the construction of imaging probes and diagnostic conjugates by linking targeting moieties to reporter molecules.
• ADC (Antibody-Drug Conjugate) Development: Provides a versatile linker platform for constructing stable, cleavable, or non-cleavable connections between antibodies and cytotoxic payloads.

Basic Information

Product Name	N3-Peg12-Oh
CAS No.	1821464-55-4
Molecular Formula	C26H53N3O13
Molecular Weight	615.71 g/mol
Synonyms	Azido-PEG12-alcohol; 1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-38-ol; 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-ol (PEG12 extended); N3-PEG12-OH; Azido-dodecaethylene glycol; HO-PEG12-N3; PEG12 azide alcohol; Heterobifunctional PEG linker, N3-PEG12-OH
EINECS	Contact for details

Quality Control

Our N3-Peg12-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical-grade applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. Allow the vial to warm to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Average Molecular Weight	600 - 630 g/mol
Functional Group Assay (N3)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.