Description

tert-Butyl 2-Chloro-5-Methylpyridin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyridine and carbamate functional groups. This compound is of significant value for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily needed by pharmaceutical manufacturers and R&D organizations focused on developing novel therapeutic agents, including kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of target drug molecules, especially within oncology and anti-inflammatory research pipelines.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery.
• API Synthesis: Used in the final stages or penultimate steps for constructing complex molecular architectures required for active pharmaceutical ingredients.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Chemistry Development: Utilized in optimizing scalable and efficient synthetic routes for pilot-scale and commercial manufacturing.
• Agrochemical Intermediate: Potential application in the synthesis of advanced crop protection agents and pesticides due to its heterocyclic structure.

Basic Information

Item	Details
Product Name	tert-Butyl 2-Chloro-5-Methylpyridin-4-Ylcarbamate
CAS No.	1820717-60-9
Molecular Formula	C12H17ClN2O2
Molecular Weight	256.73 g/mol
Synonyms	tert-Butyl (2-chloro-5-methylpyridin-4-yl)carbamate; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-chloro-5-methylpyridine; 2-Chloro-5-methyl-4-[(tert-butoxycarbonyl)amino]pyridine; 2-Chloro-5-methylpyridin-4-amine, N-Boc-protected; Boc-2-Chloro-5-methyl-4-aminopyridine; N-Boc-2-chloro-5-methyl-4-aminopyridine; 4-Amino-2-chloro-5-methylpyridine tert-butylcarbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Chloro-5-Methylpyridin-4-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.