Description

2-Amino-4-Bromo-5-Iodo-Benzoic Acid Methyl Ester is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring strategically placed amino, bromo, and iodo substituents, makes it a versatile precursor for constructing complex molecules through cross-coupling and functional group transformation reactions. This compound is primarily utilized by research institutions and pharmaceutical R&D departments engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Research: Serves as a building block in the development of novel herbicides, fungicides, and insecticides with potentially enhanced efficacy.
• Material Science: Used in the research and development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its halogenated aromatic core.
• Chemical Synthesis: Employed in Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to introduce functionalized aromatic segments.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in homogeneous catalysis.
• Academic & Industrial R&D: Essential for exploratory chemistry in university laboratories and corporate R&D centers focusing on novel chemical entities.

Basic Information

Product Name	2-Amino-4-Bromo-5-Iodo-Benzoic Acid Methyl Ester
CAS No.	1820641-86-8
Molecular Formula	C8H7BrINO2
Molecular Weight	355.96 g/mol
Synonyms	Methyl 2-Amino-4-Bromo-5-Iodobenzoate; Benzoic acid, 2-amino-4-bromo-5-iodo-, methyl ester; 4-Bromo-5-iodo-2-aminobenzoic acid methyl ester; 2-Amino-4-bromo-5-iodobenzoic acid methyl ester; Methyl 4-bromo-5-iodo-2-aminobenzoate
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4-Bromo-5-Iodo-Benzoic Acid Methyl Ester is produced and tested under stringent quality management protocols to ensure consistency and reliability for critical research and development applications. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with comprehensive identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing batch-specific results for purity, identity, and residual solvents are provided and available upon request. We support custom synthesis to meet specific purity or analytical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.