Description

(1R,4R)-4-((5-Iodopyridin-2-Yl)Oxy)Cyclohexan-1-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant interest in modern organic synthesis. Its value lies in its defined stereochemistry and functional groups, which make it a critical precursor for the development of targeted bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on discovering and scaling up novel therapeutic agents, such as kinase inhibitors or other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for targeted therapies.
• Kinase Inhibitor Synthesis: Serves as a crucial building block in the construction of potent and selective kinase inhibitor candidates for oncology and other disease areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale synthesis for the commercial production of advanced drug candidates.
• Bioconjugation & Probe Development: The amine and halogen functionalities allow for further derivatization to create molecular probes or antibody-drug conjugate (ADC) linkers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific compounds under cGMP conditions.

Basic Information

Product Name	(1R,4R)-4-((5-Iodopyridin-2-Yl)Oxy)Cyclohexan-1-Amine Hydrochloride
CAS No.	1820572-09-5
Molecular Formula	C11H16ClIN2O
Molecular Weight	354.62 g/mol
Synonyms	(1R,4R)-4-[(5-Iodo-2-pyridinyl)oxy]-1-cyclohexanamine hydrochloride; trans-4-((5-Iodopyridin-2-yl)oxy)cyclohexanamine hydrochloride; 5-Iodo-2-(((1R,4R)-4-aminocyclohexyl)oxy)pyridine hydrochloride; UNII-9R2F9F8K3I; (1R,4R)-4-((5-Iodo-2-pyridyl)oxy)cyclohexylamine HCl; 2-(((1R,4R)-4-Aminocyclohexyl)oxy)-5-iodopyridine hydrochloride
EINECS	Contact for details

Quality Control

Our production of (1R,4R)-4-((5-Iodopyridin-2-Yl)Oxy)Cyclohexan-1-Amine Hydrochloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for pharmaceutical R&D. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles is provided with every shipment. We support development under quality agreements and can supply material suitable for use in cGMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.