Description

1'‐(2‐Bromoethyl)‐1',2'‐Dihydrospiro[Cyclopropane‐ 1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One is a high-value, spirocyclic organic building block designed for advanced pharmaceutical and agrochemical research. This compound is critical for medicinal chemists seeking to develop novel small molecule therapeutics, particularly due to its unique fused ring system and reactive bromoethyl handle. It is primarily utilized by R&D teams in the pharmaceutical, biotechnology, and fine chemical synthesis sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Agrochemical Development: Serves as a building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring specialized spirocyclic frameworks.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1'‐(2‐Bromoethyl)‐1',2'‐Dihydrospiro[Cyclopropane‐ 1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One
CAS No.	1818847-40-3
Molecular Formula	C12H13BrN2O
Molecular Weight	281.15 g/mol
Synonyms	1'-(2-Bromoethyl)-1',2'-dihydrospiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; Spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridine]-2'-one, 1'-(2-bromoethyl)-1',2'-dihydro-; 1'-(2-Bromoethyl)-1',2'-dihydro-2'H-spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; CAS 1818847-40-3
EINECS	Contact for details

Quality Control

Our 1'‐(2‐Bromoethyl)‐1',2'‐Dihydrospiro[Cyclopropane‐ 1,3'‐Pyrrolo[2,3‐B]Pyridine]‐2'‐One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 standards, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.