Description

2-Azaspiro[3.3]Heptan-6-One Trifluoroacetate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value in modern medicinal chemistry for constructing complex, three-dimensional molecular architectures that can improve drug-like properties. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space with spirocyclic motifs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or core component in the design of bifunctional degraders.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche APIs.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	2-Azaspiro[3.3]Heptan-6-One Trifluoroacetate
CAS No.	1818847-38-9
Molecular Formula	C8H10F3NO3
Molecular Weight	225.17 g/mol
Synonyms	6-Oxo-2-azaspiro[3.3]heptane-2-ium trifluoroacetate; 2-Azaspiro[3.3]heptan-6-one, 2,2,2-trifluoroacetate; 2-Azonia-6-oxaspiro[3.3]heptane trifluoroacetate; 2-Azaspiro[3.3]heptan-6-one TFA salt; 6-Oxo-2-azaspiro[3.3]heptane trifluoroacetate; 2-Azaspiro[3.3]heptan-6-one trifluoroacetic acid salt; Spiro[2.4]heptan-6-one, 1-aza- (TFA salt)
EINECS	Contact for details

Quality Control

Every batch of 2-Azaspiro[3.3]Heptan-6-One Trifluoroacetate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.