Description

Azido-Peg6-Tfp Ester is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a tetrafluorophenyl (Tfp) ester. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific coupling of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require high-purity, functional linkers for creating novel drug conjugates, diagnostic probes, and biomaterials.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides for the creation of antibody-drug conjugates (ADCs) and other therapeutic biologics.
• Click Chemistry (SPAAC): Utilizes the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction with cyclooctynes for labeling and modifying biomolecules without the need for cytotoxic copper catalysts.
• PEGylation and Surface Modification: Introduction of PEG chains via the reactive Tfp ester to enhance the solubility, stability, and pharmacokinetic properties of therapeutic molecules or to functionalize nanoparticles and biosensor surfaces.
• Polymer and Materials Science: Synthesis of functionalized block copolymers, hydrogels, and smart materials by reacting the azide and ester termini with complementary functional groups.
• Diagnostic Probe Synthesis: Construction of imaging agents and diagnostic tools by linking targeting moieties to reporter molecules like dyes or radiolabels.
• Chemical Biology and Proteomics: A versatile tool for labeling, crosslinking, and studying protein-protein interactions and cellular processes.

Basic Information

Product Name	Azido-Peg6-Tfp Ester
CAS No.	1818294-50-6
Molecular Formula	C27H38F4N4O9
Molecular Weight	638.61 g/mol
Synonyms	Azido-PEG6-TFP ester; 2,3,5,6-Tetrafluorophenyl 3,6,9,12,15,18-hexaoxa-21-azadotriacont-31-yn-21-ium-21-olate; TFP-PEG6-Azide; Tetrafluorophenyl-PEG6-azide; Azido-PEG6-TFP ester; 21-Azido-3,6,9,12,15,18-hexaoxahenicosyl 2,3,5,6-tetrafluorobenzoate; N3-PEG6-TFP ester; PEG-Azide TFP Ester (6 Unit)
EINECS	Contact for details

Quality Control

Our Azido-Peg6-Tfp Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, critical for sensitive bioconjugation applications. Each lot is characterized by NMR (¹H and ¹³C) and HPLC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support development and cGMP manufacturing needs with documentation traceability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Under these conditions, the product is typically stable for 24 months from the date of receipt. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.