Description

Azido-PEG8-TFP Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a tetrafluorophenyl (TFP) ester. This compound is engineered for efficient, high-yield bioconjugation, enabling the stable linkage of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced materials science for applications such as antibody-drug conjugate (ADC) development, peptide modification, and surface functionalization.

Application

• Bioconjugation reagent for the synthesis of Antibody-Drug Conjugates (ADCs) and other protein-payload constructs.
• Functionalization of peptides, oligonucleotides, and small molecule drugs with PEG spacers via click chemistry (azide-alkyne cycloaddition).
• Surface modification of nanoparticles, hydrogels, and diagnostic chips to introduce bio-reactive groups.
• Crosslinking agent in the development of drug delivery systems and controlled-release platforms.
• Tool compound for proteomics research, including activity-based protein profiling (ABPP) and labeling studies.
• Intermediate in the synthesis of complex PEGylated linkers and building blocks for life science applications.

Basic Information

Product Name	Azido-PEG8-TFP Ester
CAS No.	1818294-49-3
Molecular Formula	C₃₀H₄₃F₄N₃O₁₂
Molecular Weight	713.67 g/mol
Synonyms	Azido-PEG8-TFP Ester; 2,3,5,6-Tetrafluorophenyl 3,6,9,12,15,18,21,24-octaoxa-2-azahexacosan-26-oate; Azido-PEG8-2,3,5,6-Tetrafluorophenyl Ester; 8-Azido-3,6,9,12,15,18,21,24-octaoxapentacosanoic Acid 2,3,5,6-Tetrafluorophenyl Ester; N3-PEG8-TFP Ester; Azido-PEG₈-TFP Ester; TFP-PEG₈-N₃; Tetrafluorophenyl Ester of Azido-octaethylene glycol
EINECS	Contact for details

Quality Control

Our Azido-PEG8-TFP Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.