Description

Azido-PEG12-t-butyl ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a protected carboxylic acid terminus. This compound is a critical building block in bioconjugation and materials science, enabling the creation of stable linkages via click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing targeted drug delivery systems, functionalized surfaces, and novel polymeric materials.

Application

• Bioconjugation reagent for linking biomolecules (e.g., peptides, antibodies, oligonucleotides) to other entities via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• Functionalization of nanoparticles, quantum dots, and liposomes to create targeted diagnostic and therapeutic agents.
• Synthesis of PEGylated prodrugs and antibody-drug conjugates (ADCs) to improve solubility, stability, and pharmacokinetics.
• Surface modification of biomaterials and medical devices to enhance biocompatibility and introduce specific functional groups.
• Crosslinker in the development of hydrogels and smart polymeric materials for controlled release applications.
• Intermediate in the synthesis of more complex heterobifunctional and multi-arm PEG derivatives for specialized research applications.
• Tool compound in chemical biology for labeling and studying cellular processes.

Basic Information

Product Name	Azido-PEG12-t-butyl ester
CAS No.	1818294-45-9
Molecular Formula	C33H65N3O14
Molecular Weight	703.88 g/mol
Synonyms	Azido-PEG12-COOtBu; 1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-38-oic acid tert-butyl ester; tert-Butyl azido-dodecaethylene glycol) carboxylate; N3-PEG12-t-butyl ester; Azido-PEG12-acid t-butyl ester; Azido-PEG12-T-Butyl Ester; PEG12 azide t-butyl ester; Azido-PEG12-tBu ester
EINECS	Contact for details

Quality Control

Our Azido-PEG12-t-butyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Integrity (NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.