Description

Azido-Peg9-T-Butyl Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a protected carboxylic acid terminus. This compound is a critical building block in bioconjugation and click chemistry, enabling the efficient, site-specific linkage of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require precise and stable cross-linking strategies.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry (CuAAC).
• PEGylation Reagent: Serves to introduce a hydrophilic PEG spacer with a protected carboxyl group, which can be deprotected and further functionalized to modify the pharmacokinetic properties of therapeutic proteins and peptides.
• Surface Functionalization: Employed to create azide-terminated surfaces on nanoparticles, biosensors, or medical devices for subsequent bio-orthogonal coupling of alkyne-modified ligands or biomolecules.
• Polymer and Dendrimer Synthesis: Acts as a versatile monomer or cross-linker in the synthesis of functionalized polymers and dendrimers with tailored properties for drug delivery and diagnostic applications.
• Chemical Biology Probes: Utilized to synthesize activity-based probes or affinity tags for labeling and studying biological targets in complex cellular environments.

Basic Information

Product Name	Azido-Peg9-T-Butyl Ester
CAS No.	1818294-43-7
Molecular Formula	C28H55N3O12
Molecular Weight	625.75 g/mol
Synonyms	Azido-PEG9-t-butyl ester; 1-Azido-3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-30-oic acid tert-butyl ester; tert-Butyl 3,6,9,12,15,18,21,24,27-nonaoxa-30-azidodotriacontanoate; Azido-PEG9-COOtBu; N3-PEG9-t-butyl ester; PEG9 azide t-butyl ester; Azido-PEG9-acid t-butyl ester; Heterobifunctional PEG Azide t-Butyl Ester
EINECS	Contact for details

Quality Control

Our Azido-Peg9-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.