Description

Amino-Peg10-T-Butyl Ester is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive primary amine group and a protected carboxylic acid terminus. This compound is engineered to serve as a critical building block in bioconjugation and linker chemistry, enabling the precise modification of biomolecules and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-quality PEGylation reagents for drug delivery systems, diagnostic assays, and hydrogel fabrication.

Application

• Bioconjugation and Linker Chemistry: Acts as a versatile spacer and linker for attaching drugs, peptides, or fluorescent dyes to antibodies, proteins, and nanoparticles.
• Drug Delivery System Development: Used to create PEGylated prodrugs and to functionalize liposomes or polymeric micelles to enhance solubility, stability, and circulation time.
• Surface Functionalization: Employed to modify surfaces (e.g., gold, silica, polymers) with amine-reactive groups for biosensor and microarray applications.
• Cross-linking Agent: Serves as a hydrophilic cross-linker in the synthesis of hydrogels for tissue engineering and controlled release matrices.
• Diagnostic Reagent Synthesis: Integral in the production of labeled antibodies and antigens for immunoassays (ELISA, lateral flow tests).
• ADC (Antibody-Drug Conjugate) Payload Attachment: Provides a cleavable or non-cleavable PEG spacer for connecting cytotoxic drugs to monoclonal antibodies.

Basic Information

Product Name	Amino-Peg10-T-Butyl Ester
CAS No.	1818294-42-6
Molecular Formula	C31H63NO13
Molecular Weight	657.8 g/mol
Synonyms	t-Butyl-PEG10-amine; 1-Amino-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-32-oic acid tert-butyl ester; tert-Butyl 1-amino-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-32-oate; Amino-PEG10-t-butyl ester; NH2-PEG10-COOtBu; Amine-PEG10-acid t-butyl ester; Heterobifunctional PEG 10, amine, t-butyl ester; tert-Butyl-PEG10-NH2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms
Functional Group Assay (Amine Titration)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.