Description

Trityl-Peg7-Azide is a specialized, heterobifunctional polyethylene glycol (PEG) linker featuring a trityl (triphenylmethyl) protecting group and a terminal azide functionality. This compound is engineered for high-value applications in bioconjugation and advanced materials science, offering controlled reactivity and enhanced solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors for the synthesis of antibody-drug conjugates (ADCs), peptide modifications, and the development of PEGylated hydrogels and surfaces.

Application

• Bioconjugation & ADC Development: Serves as a key linker for site-specific conjugation of cytotoxic drugs to monoclonal antibodies, enabling the creation of next-generation antibody-drug conjugates (ADCs) with improved stability and therapeutic index.
• Peptide & Protein Modification: Used to introduce PEG chains (PEGylation) onto peptides or proteins via click chemistry (e.g., with alkynes), enhancing their solubility, stability, and circulation half-life.
• Polymer & Materials Science: Acts as a functional monomer or cross-linker in the synthesis of smart hydrogels, surface coatings, and functionalized nanoparticles for drug delivery and biosensing applications.
• Diagnostic Probe Synthesis: Facilitates the labeling of biomarkers, antibodies, or oligonucleotides with fluorescent dyes or other reporter molecules through efficient azide-alkyne cycloaddition reactions.
• Solid-Phase Peptide Synthesis (SPPS): The acid-labile trityl group allows for its use as an orthogonal protecting group in multi-step synthetic strategies on solid support.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and the development of chemical probes to study biological processes and protein function.

Basic Information

Product Name	Trityl-Peg7-Azide
CAS No.	1818294-30-2
Molecular Formula	C46H61N3O8
Molecular Weight	784.0 g/mol
Synonyms	Trityl-PEG7-N3; α-Trityl-ω-azido-hepta(ethylene glycol); Triphenylmethyl-PEG7-azide; N3-PEG7-Trt; Azido-PEG7-trityl alcohol; 2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, 1-trityl ether; Heptaethylene glycol monooctadecyl ether, 1-trityl ether (related); Trt-PEG7-N3
EINECS	Contact for details

Quality Control

Our Trityl-Peg7-Azide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive research and GMP-grade applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. For long-term storage, consider storing at -20°C under desiccant.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DCM, DMF, DMSO, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.