Description

S-Acetyl-Peg3-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a protected carboxylic acid group and an acetylated terminal hydroxyl. This compound is a critical building block in the synthesis of complex molecules, offering controlled solubility and conjugation capabilities. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation industries for developing advanced drug delivery systems, prodrugs, and diagnostic agents.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile spacer and linker in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Prodrug Synthesis: Used to create water-soluble prodrugs by conjugating active pharmaceutical ingredients (APIs) via the cleavable ester linkage.
• Polymer Modification: Acts as a functional monomer or terminating agent for modifying polymers to enhance biocompatibility and pharmacokinetic properties.
• Bioconjugation: Facilitates the site-specific attachment of peptides, proteins, or fluorescent dyes for diagnostic and research applications.
• Material Science: Employed in the surface functionalization of nanoparticles and biomaterials to improve stability and targeting.
• Chemical Biology Tools: A key reagent for developing probes and tools to study biological processes and interactions.

Basic Information

Product Name	S-Acetyl-Peg3-T-Butyl Ester
CAS No.	1818294-27-7
Molecular Formula	C17H32O7
Molecular Weight	348.44 g/mol
Synonyms	1-Acetyl-3,6,9-trioxa-12-azatetradecan-14-oic acid tert-butyl ester; tert-Butyl 2,5,8,11-tetraoxatetradecan-14-oate-13-acetate; S-Acetyl-PEG3-t-butyl ester; Ac-Peg3-OtBu; Acetyl-PEG3-acid t-butyl ester; 13-Acetyl-2,5,8,11-tetraoxatetradecan-14-oic acid tert-butyl ester; PEG3-Acetyl-t-butyl ester
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.