Description

Azido-Peg2-Sulfonic Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a sulfonic acid terminus. This unique structure is critical for creating stable, water-soluble conjugates in advanced bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and the synthesis of functionalized surfaces and hydrogels.

Application

• Bioconjugation Reagent: Used for "click chemistry" via copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach biomolecules like peptides, proteins, or oligonucleotides to surfaces or other molecules.
• ADC (Antibody-Drug Conjugate) Linker Development: Serves as a functional spacer in the design of novel ADC linkers, leveraging the sulfonic acid group for enhanced solubility.
• Surface Functionalization: Modifies nanoparticles, chips, or sensor surfaces with azide groups for subsequent specific biomolecule immobilization.
• Polymer and Hydrogel Synthesis: Acts as a crosslinking agent or functional monomer to introduce negative charge (via sulfonate) and reactivity into polymeric networks.
• Proteomics and Biomarker Discovery: Employed in chemical proteomics strategies for labeling and enriching target proteins.
• Diagnostic Reagent Formulation: Used in the development of diagnostic assays where stable, water-soluble linker chemistry is required.

Basic Information

Product Name	Azido-Peg2-Sulfonic Acid
CAS No.	1817735-39-9
Molecular Formula	C7H15N3O6S
Molecular Weight	269.28 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]ethanesulfonic Acid; Azido-PEG2-sulfonic Acid; 3,6-Dioxa-8-azidooctane-1-sulfonic Acid; 2,5,8-Trioxa-11-aza-1-undecanesulfonic acid, 11-azido-; Azido-EG2-sulfonic Acid; Azido-(PEG)2-sulfonic Acid; N3-PEG2-SO3H; Azido-PEG2-Sulfonate
EINECS	Contact for details

Quality Control

Our Azido-Peg2-Sulfonic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Assay (NMR)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.