Description

1,1,1-Trifluoroethyl-Peg4-Azide is a specialized bifunctional linker molecule featuring a reactive azide group and a poly(ethylene glycol) spacer terminated with a trifluoroethyl moiety. This compound is engineered to enable efficient, site-specific bioconjugation via click chemistry, offering enhanced solubility and stability in aqueous and organic systems. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require precise and reliable cross-linking agents.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry.
• Proteomics and Biomolecule Labeling: Used for tagging proteins, peptides, and oligonucleotides with fluorescent dyes, affinity tags, or other functional probes for imaging and detection.
• Polymer and Materials Science: Acts as a functional monomer or cross-linker for synthesizing smart hydrogels, surface coatings, and functionalized nanoparticles with tailored properties.
• Chemical Biology and Drug Discovery: Facilitates the construction of chemical libraries and the development of PROTACs (Proteolysis Targeting Chimeras) by linking target binders to E3 ligase ligands.
• Diagnostic Reagent Formulation: Employed in the development of diagnostic assays and biosensors where stable, covalent attachment of recognition elements is required.

Basic Information

Product Name	1,1,1-Trifluoroethyl-Peg4-Azide
CAS No.	1817735-35-5
Molecular Formula	C15H26F3N3O4
Molecular Weight	369.38 g/mol
Synonyms	2,2,2-Trifluoroethyl-PEG4-azide; 1-Azido-3,6,9,12-tetraoxapentadecan-15-yl 2,2,2-trifluoroacetate; 2,2,2-Trifluoroethyl tetraethylene glycol azide; Azido-PEG4-2,2,2-trifluoroethyl ester; Trifluoroethyl-PEG4-N3; 15-Azido-3,6,9,12-tetraoxapentadecan-1-yl 2,2,2-trifluoroacetate; TFEA-PEG4-N3
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoroethyl-Peg4-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. The product is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from strong acids and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.