Description

Methyl 6-Aminospiro[3.3]heptane-2-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, offering a constrained, three-dimensional structure that is highly sought after for creating novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of rigid, spirocyclic geometry on potency, selectivity, and metabolic stability.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns in drug discovery.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein function.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for methodological development and the study of spirocyclic compound chemistry.

Basic Information

Product Name	Methyl 6-Aminospiro[3.3]heptane-2-carboxylate
CAS No.	1808253-04-4
Molecular Formula	C10H15NO2
Molecular Weight	181.23 g/mol
Synonyms	Methyl 6-amino-2-spiro[3.3]heptane-2-carboxylate; 6-Aminospiro[3.3]heptane-2-carboxylic acid methyl ester; 2-Carbomethoxy-6-aminospiro[3.3]heptane; Methyl 2-amino-6-spiro[3.3]heptanecarboxylate (regioisomer); 6-Azaspiro[3.3]heptane-2-carboxylic acid, 6-amino-, methyl ester; Spiro[3.3]heptane-2-carboxylic acid, 6-amino-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 6-Aminospiro[3.3]heptane-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) documenting full specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.