Description

4-Bromo-2,3-difluoro-6-iodo-1-(trimethylsilyl)benzene is a highly functionalized, multi-halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. This compound matters because its unique combination of bromo, fluoro, iodo, and silyl groups offers versatile reactivity for constructing complex molecules with precise electronic and steric properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions, fluorinated drug discovery, and the synthesis of liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging its halogen diversity for selective coupling reactions.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides where fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Material Science: Serves as a monomer or building block for advanced polymers, organic semiconductors, and liquid crystal displays (LCDs) due to the influence of the trimethylsilyl and halogen groups on material properties.
• Cross-Coupling Reactions: An excellent substrate for various metal-catalyzed reactions, including Suzuki, Stille, and Negishi couplings, where the different halogens offer orthogonal reactivity.
• Fluorination Chemistry: Acts as a starting material or intermediate for further selective fluorination or functional group transformations in medicinal chemistry programs.
• Chemical Synthesis Reference Standard: Used as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	4-Bromo-2,3-difluoro-6-iodo-1-(trimethylsilyl)benzene
CAS No.	1807646-35-0
Molecular Formula	C9H8BrF2ISi
Molecular Weight	404.96 g/mol
Synonyms	1-Bromo-2,3-difluoro-4-iodo-5-(trimethylsilyl)benzene; Benzene, 1-bromo-2,3-difluoro-4-iodo-5-(trimethylsilyl)-; 4-Bromo-2,3-difluoro-6-iodophenyltrimethylsilane; TMS-Protected Polyhalogenated Benzene; Trimethyl(4-bromo-2,3-difluoro-6-iodophenyl)silane
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,3-difluoro-6-iodo-1-(trimethylsilyl)benzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.