Description

2,3-Difluoro-6-Iodo-1-(Trimethylsilyl)Benzene is a high-value, multi-functional organosilicon intermediate with a unique halogenated aromatic structure. Its combination of iodine and fluorine substituents makes it a critical building block for advanced material synthesis and pharmaceutical research, offering precise control over molecular architecture. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules, particularly in cross-coupling reactions and as a precursor for liquid crystal materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in creating novel herbicides and pesticides where the difluoro and iodo groups contribute to biological activity and environmental stability.
• Material Science Precursor: Acts as a foundational monomer for synthesizing advanced polymers, organic semiconductors, and liquid crystal display (LCD) materials.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form complex biaryl systems.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for late-stage functionalization and introducing the trimethylsilyl group as a protective moiety or directing group.
• Chemical Research & Development: Essential for academic and industrial R&D focused on developing new synthetic methodologies and exploring structure-activity relationships.

Basic Information

Product Name	2,3-Difluoro-6-Iodo-1-(Trimethylsilyl)Benzene
CAS No.	1807646-33-8
Molecular Formula	C9H11F2ISi
Molecular Weight	312.17 g/mol
Synonyms	1-Iodo-2,3-difluoro-4-(trimethylsilyl)benzene; 2,3-Difluoro-6-iodophenyltrimethylsilane; (2,3-Difluoro-6-iodophenyl)trimethylsilane; Benzene, 2,3-difluoro-6-iodo-1-(trimethylsilyl)-; TMS-2,3-difluoro-6-iodobenzene; 6-Iodo-2,3-difluorophenyltrimethylsilane
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-Iodo-1-(Trimethylsilyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.