Description

Mal-Amido-Peg4-Tfp Ester is a heterobifunctional, amine-to-sulfhydryl reactive crosslinking reagent featuring a maleimide group and a tetrafluorophenyl (TFP) ester. This compound is engineered for efficient, site-specific bioconjugation, offering superior stability and reaction kinetics compared to traditional NHS esters. It is essential for researchers and manufacturers developing stable antibody-drug conjugates (ADCs), peptide-protein conjugates, and other advanced therapeutic and diagnostic bioconjugates. The product is supplied under stringent quality control to ensure batch-to-batch reproducibility for critical life science and pharmaceutical applications.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to cysteine residues on monoclonal antibodies.
• Peptide & Protein Labeling: Introduction of fluorophores, biotin, or other probes onto cysteine-containing biomolecules.
• Surface Functionalization: Immobilization of thiolated ligands, peptides, or proteins onto maleimide-activated surfaces or particles.
• Polymer & Biomaterial Modification: Crosslinking agent for synthesizing hydrogels or functionalizing polymeric carriers for drug delivery.
• Diagnostic Reagent Synthesis: Construction of stable immunoconjugates for ELISA, lateral flow assays, and other diagnostic platforms.
• Stable Intermediate Synthesis: Used as a building block for creating more complex, custom heterobifunctional crosslinkers.

Basic Information

Item	Details
Product Name	Mal-Amido-Peg4-Tfp Ester
CAS No.	1807540-84-6
Molecular Formula	C26H30F4N2O10
Molecular Weight	606.53 g/mol
Synonyms	Maleimide-PEG4-TFP Ester; TFP-PEG4-Maleimide; 2,3,5,6-Tetrafluorophenyl 3-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoate; 4-Arm PEG-TFP Ester (related); Tetrafluorophenyl ester-PEG4-maleimide; Amine-to-Sulfhydryl Crosslinker, PEG4 Spacer; Heterobifunctional PEG Crosslinker, Mal-PEG4-TFP; CAS 1807540-84-6
EINECS	Contact for details

Quality Control

Every batch of Mal-Amido-Peg4-Tfp Ester is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and performance. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and mass spectrometry. Our production adheres to cGMP guidelines where applicable, supporting its use in pre-clinical and clinical-stage biopharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.