Description

Azido-Peg3-Tfp Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a tetrafluorophenyl (Tfp) ester. This compound is a critical reagent for bioorthogonal conjugation, enabling efficient and selective modification of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications such as antibody-drug conjugate (ADC) development, protein labeling, and surface functionalization of nanoparticles and biomaterials.

Application

• Antibody-Drug Conjugate (ADC) Development: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry.
• Protein and Peptide Modification: Used for the PEGylation and functionalization of proteins, peptides, and enzymes to enhance stability, solubility, or pharmacokinetic properties.
• Biomaterial and Hydrogel Synthesis: Serves as a crosslinking agent for creating functionalized hydrogels and polymer scaffolds for tissue engineering and drug delivery systems.
• Surface Functionalization: Enables the covalent attachment of biomolecules to surfaces, nanoparticles, or diagnostic beads for biosensor and assay development.
• Chemical Biology Probes: Acts as a key building block for synthesizing activity-based probes and affinity tags to study protein function and interactions.
• Polymer Chemistry: Employed in the synthesis of functionalized block copolymers and dendrimers with precise chemical handles.

Basic Information

Product Name	Azido-Peg3-Tfp Ester
CAS No.	1807540-76-6
Molecular Formula	C₂₀H₂₄F₄N₄O₇
Molecular Weight	508.43 g/mol
Synonyms	Azido-PEG3-TFP Ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate, Tetrafluorophenyl ester analog; 11-Azido-3,6,9-trioxaundecan-1-oic acid 2,3,5,6-tetrafluorophenyl ester; TFP-PEG3-Azide; Tetrafluorophenyl-PEG3-azide; Azido-PEG3-TFP; N3-PEG3-TFP Ester; PEG-based heterobifunctional crosslinker with azide and TFP ester
EINECS	Contact for details

Quality Control

Our Azido-Peg3-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive conjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.