Description

Azido-PEG4-acrylate is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a terminal azide group and an acrylate ester. This compound is essential for creating stable, biocompatible conjugates via orthogonal click chemistry and photopolymerization reactions. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, hydrogel development, and advanced material science for applications ranging from drug delivery systems to surface functionalization.

Application

• Bioconjugation and Protein Labeling: The azide group enables efficient, site-specific conjugation to alkyne-modified biomolecules (via CuAAC or SPAAC click chemistry) for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Hydrogel and Biomaterial Synthesis: The acrylate terminus allows for incorporation into polymer networks via UV or redox-initiated polymerization, creating PEG-based hydrogels for 3D cell culture, tissue engineering, and controlled release matrices.
• Surface Modification and Functionalization: Used to graft PEG brushes or specific functional groups onto surfaces (e.g., nanoparticles, chips, medical devices) to impart stealth properties, reduce non-specific binding, or introduce bio-recognition elements.
• Linker for Drug Delivery Systems: Serves as a cleavable or non-cleavable spacer in prodrug designs and nanocarriers, leveraging the PEG chain to enhance solubility, prolong circulation time, and reduce immunogenicity.
• Chemical Biology Probes: A key building block for synthesizing activity-based probes or photoaffinity labels to study protein function and interactions in complex biological systems.
• Polymer Chemistry: Acts as a functional monomer or crosslinker in the synthesis of smart polymers and functional materials with tailored properties.

Basic Information

Product Name	Azido-PEG4-acrylate
CAS No.	1807539-09-8
Molecular Formula	C₁₆H₂₇N₃O₇
Molecular Weight	373.40 g/mol
Synonyms	Azido-PEG4-Acrylate; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-azido-14-oxo-, 2-propen-1-yl ester; 3-Azidopropyl (2,5,8,11-tetraoxatetradecan-14-yl) acrylate; Acrylate-PEG4-azide; Azido-PEG4-Acrylate ester; Azido tetraethylene glycol acrylate; N3-PEG4-Acrylate; PEG4-Azide Acrylate
EINECS	Contact for details

Quality Control

Our Azido-PEG4-acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.