Description

Peg4-Bis(Phosphonic Acid Diethyl Ester) CAS NO 1807539-03-2 is a specialized bifunctional organophosphorus compound featuring a tetraethylene glycol (PEG4) spacer terminated by diethyl phosphonate groups. This molecular architecture is critical for its role as a versatile building block and coupling agent in advanced material science and pharmaceutical development. It is primarily sought by researchers and manufacturers in the fields of bioconjugation, surface modification, and the synthesis of complex ligands for catalysis and metal chelation.

Application

• Bioconjugation & Linker Chemistry: Serves as a hydrophilic, flexible linker for attaching biomolecules (e.g., peptides, antibodies) to surfaces, nanoparticles, or other functional molecules.
• Surface Functionalization: Used to modify metal oxide surfaces (e.g., titanium, silica) with phosphonate anchoring groups, creating stable, non-fouling coatings for medical implants and biosensors.
• Ligand Synthesis: Acts as a key precursor for synthesizing complex multidentate ligands used in homogeneous catalysis and metal ion sequestration.
• Polymer & Dendrimer Modification: Incorporated into polymer backbones or dendrimer peripheries to introduce phosphonate functionality, enhancing properties like hydrophilicity and metal-binding capacity.
• Material Science Research: Employed in developing novel self-assembled monolayers (SAMs) and hybrid organic-inorganic materials with tailored interfacial properties.

Basic Information

Product Name	Peg4-Bis(Phosphonic Acid Diethyl Ester)
CAS No.	1807539-03-2
Molecular Formula	C16H36O10P2
Molecular Weight	450.40 g/mol
Synonyms	Diethyl (((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(phosphonate); Tetraethylene glycol bis(diethyl phosphonate); Bis(2-(2-(2-(2-(diethoxyphosphoryl)ethoxy)ethoxy)ethoxy)ethyl) phosphonate; 1,11-Bis(diethylphosphonyl)-3,6,9-trioxaundecane; PEG4-bisphosphonate diethyl ester; 2,2'-(2,2'-(2,2'-(Oxydi-2,1-ethanediyl)bis(oxy))bis(2,1-ethanediyl)oxy)bis(ethane-2,1-diyl) bis(diethylphosphonate)
EINECS	Contact for details

Quality Control

Our Peg4-Bis(Phosphonic Acid Diethyl Ester) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets high-purity research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.