Description

Azido-Peg2-Tfp Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a tetrafluorophenyl (Tfp) ester. This compound is engineered for efficient, site-specific bioconjugation, enabling the stable attachment of biomolecules under mild aqueous conditions. It is an essential reagent for researchers and developers in pharmaceutical R&D, proteomics, and advanced materials science, particularly for creating antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via click chemistry.
• Peptide and Protein Labeling: Introduction of azide handles for subsequent bioorthogonal ligation (e.g., with DBCO or cyclooctyne reagents).
• Surface Functionalization: Modification of nanoparticles, biosensors, or microarray slides with bioactive ligands.
• Polymer Chemistry: Synthesis of functionalized PEG-based hydrogels and block copolymers for drug delivery systems.
• Diagnostic Reagent Synthesis: Preparation of labeled probes and imaging agents for in vitro and in vivo applications.
• Biomaterial Engineering: Covalent crosslinking to create tailored matrices for tissue engineering and controlled release.

Basic Information

Item	Detail
Product Name	Azido-Peg2-Tfp Ester
CAS No.	1807534-87-7
Molecular Formula	C₁₉H₂₀F₄N₄O₆
Molecular Weight	476.38 g/mol
Synonyms	Azido-PEG2-TFP ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate, TFP ester derivative; 11-Azido-3,6,9-trioxaundecanoic acid tetrafluorophenyl ester; Azido-PEG2-acid TFP ester; N-(Azido-PEG2)-TFP ester; Tetrafluorophenyl 11-azido-3,6,9-trioxaundecanoate; Azido-PEG2-TFP; Heterobifunctional PEG crosslinker, Azide-TFP ester
EINECS	Contact for details

Quality Control

Every batch of Azido-Peg2-Tfp Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and lot-to-lot consistency through HPLC, NMR, and mass spectrometry analysis. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each shipment to support your GMP-compliant or research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.