Description

Azido-Peg1-Tfp Ester is a specialized heterobifunctional crosslinker featuring an azide group and a tetrafluorophenyl (Tfp) ester. This compound is engineered for efficient and selective bioconjugation, enabling the stable attachment of biomolecules under mild, aqueous conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science, particularly for creating antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of cytotoxic drugs to antibodies or proteins via click chemistry and amine coupling.
• Proteomics Research: Labeling and crosslinking of peptides and proteins for mass spectrometry analysis and interaction studies.
• Polymer and Biomaterial Functionalization: Introducing azide functionalities into hydrogels, nanoparticles, and other polymeric scaffolds for subsequent modification.
• Diagnostic Reagent Synthesis: Preparation of labeled probes and imaging agents for diagnostic assays.
• Surface Immobilization: Covalent attachment of biomolecules to sensor chips, microarray slides, and other solid supports.
• Chemical Biology Tool Development: Creating activity-based probes and other tools for studying enzymatic activity and cellular processes.

Basic Information

Item	Details
Product Name	Azido-Peg1-Tfp Ester
CAS No.	1807530-09-1
Molecular Formula	C13H11F4N3O3
Molecular Weight	333.24 g/mol
Synonyms	1-Azido-2-(2-(2,3,5,6-tetrafluorophenoxy)ethoxy)ethane; Azido-PEG1-TFP ester; 2-[2-(2,3,5,6-Tetrafluorophenoxy)ethoxy]ethyl azide; TFP-PEG1-Azide; Tetrafluorophenyl-PEG1-azide; Azido-PEG1-tetrafluorophenyl ester; PEG1-azide-TFP ester
EINECS	Contact for details

Quality Control

Our Azido-Peg1-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets the high standards required for research and GMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.