Description

Azido-Peg3-Pfp Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a pentafluorophenyl (PFP) ester. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific modification of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science industries for developing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized hydrogels.

Application

• Bioconjugation and ADC Development: Site-specific coupling of cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry.
• PEGylation and Polymer Modification: Introducing hydrophilic PEG spacers to therapeutic molecules or functionalizing polymer backbones to enhance solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: Creating bio-active surfaces on nanoparticles, chips, or medical devices by reacting the PFP ester with surface amines, followed by click chemistry with alkyne-tagged ligands.
• Crosslinking Agent: Serving as a versatile linker in the synthesis of hydrogels, dendrimers, and other three-dimensional macromolecular structures for drug delivery and tissue engineering.
• Chemical Probe Synthesis: Fabrication of activity-based probes and diagnostic agents for imaging and target identification in biological systems.

Basic Information

Product Name	Azido-Peg3-Pfp Ester
CAS No.	1807530-07-9
Molecular Formula	C19H21F5N4O6
Molecular Weight	496.39 g/mol
Synonyms	Azido-PEG3-PFP ester; 11-Azido-3,6,9-trioxaundecan-1-yl 2,3,4,5,6-pentafluorobenzoate; Pentafluorophenyl 11-azido-3,6,9-trioxaundecanoate; Azido-PEG3-PFP ester; N3-PEG3-PFP ester; PFP-PEG3-N3; Heterobifunctional PEG crosslinker, Azide-PFP; 2,3,4,5,6-Pentafluorophenyl 11-azido-3,6,9-trioxaundecanoate
EINECS	Contact for details

Quality Control

Our Azido-Peg3-Pfp Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.