Description

Ald-Ph-Peg4-T-Butyl Ester CAS NO 1807518-64-4 is a specialized bifunctional PEG derivative featuring a terminal aldehyde group and a tert-butyl ester-protected carboxylic acid. This compound is engineered to serve as a versatile heterobifunctional crosslinker and spacer arm for advanced bioconjugation and materials science applications. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and diagnostic sectors for the precise modification of peptides, proteins, and surfaces.

Application

• Bioconjugation and Protein Modification: Used as a heterobifunctional linker to covalently attach biomolecules, such as antibodies or enzymes, to other proteins, peptides, or solid supports.
• PEGylation Reagent: Acts as a functionalized PEG spacer to introduce hydrophilic polyethylene glycol chains onto drug molecules or surfaces, improving solubility and stability.
• Surface Functionalization: Enables the creation of aldehyde-activated surfaces for immobilizing amine-containing ligands in biosensor and microarray development.
• Polymer and Dendrimer Synthesis: Serves as a building block for constructing complex polymeric architectures and drug delivery systems via its orthogonal reactive groups.
• Diagnostic Reagent Synthesis: Employed in the development of immunoassay components and fluorescent probes where controlled linkage is critical.
• Click Chemistry and Material Science: Provides a handle for further chemical transformation, facilitating advanced material design and hydrogel formation.

Basic Information

Product Name	Ald-Ph-Peg4-T-Butyl Ester
CAS No.	1807518-64-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4,7,10,13-Tetraoxa-16-azaheptadecan-17-oic acid, 16-(4-formylphenyl)-, 1,1-dimethylethyl ester; Ald-Ph-PEG4-t-butyl ester; Fmoc-Ph-PEG4-CH2CH2COOH; tert-Butyl 2,5,8,11-tetraoxa-14-azahexadecan-16-oate-15-(4-formylphenyl); Heterobifunctional PEG Aldehyde t-Butyl Ester; 4-Formylbenzyl-PEG4-t-butyl ester; Benzaldehyde-PEG4-acid t-butyl ester; Amino-PEG4-acid t-butyl ester derivative
EINECS	Contact for details

Quality Control

Our Ald-Ph-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with high-purity research-grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.