Description

m-Peg5-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG derivative featuring a phosphonic acid ethyl ester moiety. This compound is engineered to serve as a versatile linker and modifier, enabling precise control over solubility, stability, and surface interactions in advanced formulations. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors who require reliable, high-quality building blocks for drug delivery systems, diagnostic probes, and functional polymers.

Application

• Pharmaceutical Intermediates: A key building block for the synthesis of prodrugs and targeted therapeutic conjugates.
• Bioconjugation & Linker Chemistry: Used to attach bioactive molecules (e.g., peptides, antibodies) to carriers, nanoparticles, or surfaces via its reactive phosphonic ester group.
• Polymer Modification: Imparts hydrophilicity and specific functionality to polymers for creating smart materials and hydrogels.
• Surface Functionalization: Modifies the properties of inorganic surfaces (e.g., metal oxides) for improved biocompatibility or specific binding in biosensors and diagnostic devices.
• Drug Delivery Systems: Incorporated into micelles, liposomes, and dendrimers to enhance solubility, stability, and controlled release profiles of active pharmaceutical ingredients (APIs).
• Research & Development: Serves as a critical reagent in chemical biology and medicinal chemistry research for exploring new therapeutic modalities.

Basic Information

Product Name	m-Peg5-Phosphonic Acid Ethyl Ester
CAS No.	1807512-42-0
Molecular Formula	C15H33O9P
Molecular Weight	388.39 g/mol
Synonyms	2-[2-[2-[2-[2-(Diethoxyphosphoryl)ethoxy]ethoxy]ethoxy]ethoxy]ethanol; 3,6,9,12-Tetraoxapentadecan-15-ol, 15-phosphono-, diethyl ester; mPEG5-phosphonic acid diethyl ester; (Ethylene glycol)5-methyl ether phosphonic acid diethyl ester; HO-PEG5-P(O)(OEt)2; Diethyl (8-hydroxy-3,6-dioxaoctyl)phosphonate PEG derivative; Phosphonic acid, P-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]-, diethyl ester
EINECS	Contact for details

Quality Control

Our m-Peg5-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets exacting standards for research and production. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.