Description

Azido-Peg4-Tfp Ester is a heterobifunctional crosslinker featuring an azide group for copper-free click chemistry and a tetrafluorophenyl (Tfp) ester for efficient amine coupling. This compound is essential for creating stable, site-specific bioconjugates under mild, aqueous conditions, making it invaluable for advanced research and development. It is primarily used by scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and proteomics research.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of antibodies, proteins, and peptides via the reactive Tfp ester group, followed by click chemistry ligation.
• Antibody-Drug Conjugate (ADC) Synthesis: Facilitating the stable attachment of cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
• Polymer and Surface Functionalization: Introducing azide handles onto materials, nanoparticles, or hydrogels for subsequent bio-orthogonal conjugation.
• Chemical Biology and Proteomics: As a key reagent for activity-based protein profiling (ABPP) and the study of protein-protein interactions.
• Diagnostic Reagent Development: Creating fluorescent or other detection probes for immunoassays and imaging applications.
• Linker for Solid-Phase Synthesis: Employed in peptide and oligonucleotide synthesis to introduce functional groups or cleavable links.

Basic Information

Product Name	Azido-Peg4-Tfp Ester
CAS No.	1807505-33-4
Molecular Formula	C₂₃H₃₁F₄N₅O₈
Molecular Weight	581.52 g/mol
Synonyms	Azido-PEG4-TFP ester; 2,3,5,6-Tetrafluorophenyl 3,6,9,12-tetraoxa-2-azatetradecan-14-oate 1-oxide; 11-Azido-3,6,9-trioxaundecan-1-yl 2,3,5,6-tetrafluorobenzoate; TFP-PEG4-Azide; Tetrafluorophenyl-PEG4-azide; Azido-PEG4-2,3,5,6-tetrafluorophenyl ester; PEG4-Azide-TFP ester; N3-PEG4-TFP ester
EINECS	Contact for details

Quality Control

Our Azido-Peg4-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.