Description

Bromo-Peg4-Ch2Cootbu is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal bromo group and a tert-butyl ester-protected carboxylic acid. This bifunctional linker is engineered for precise bioconjugation and chemical synthesis, offering controlled reactivity and enhanced solubility in aqueous and organic media. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors, enabling the development of targeted drug delivery systems, diagnostic probes, and functional polymers.

Application

• Bioconjugation and ADC Development: Serves as a versatile heterobifunctional crosslinker for attaching cytotoxic drugs, fluorescent dyes, or targeting ligands to antibodies, proteins, or peptides in Antibody-Drug Conjugate (ADC) and diagnostic reagent production.
• Polymer and Material Science: Acts as a key monomer or functionalization agent for synthesizing PEG-based hydrogels, smart polymers, and surface coatings, imparting biocompatibility and specific chemical handles.
• Prodrug Synthesis: Utilized to create PEGylated prodrugs, where the tert-butyl ester can be cleaved to release the active pharmaceutical ingredient, improving drug solubility and pharmacokinetics.
• Chemical Biology Probes: Enables the site-specific labeling of biomolecules for studies in cellular imaging, protein interaction mapping, and assay development.
• Nanoparticle Functionalization: Used to modify the surface of liposomes, dendrimers, or inorganic nanoparticles, enhancing their stability, targeting capability, and stealth properties in vivo.
• Solid-Phase Peptide Synthesis (SPPS): Functions as a soluble PEG-based scaffold or as a building block to introduce functional groups during peptide chain assembly.

Basic Information

Product Name	Bromo-Peg4-Ch2Cootbu
CAS No.	1807505-29-8
Molecular Formula	C19H37BrO8
Molecular Weight	473.40 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-bromo-3,6,9,12-tetraoxa-2-azatetradecan-1-yl-1,1-dimethylethyl ester; 1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; Bromo-PEG4-CH2COOtBu; Bromo-PEG4-acid-t-butyl ester; tert-Butyl 2-(2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)ethoxy)acetate; 15-Bromo-3,6,9,12-tetraoxapentadecanoic acid tert-butyl ester; Bromo-PEG4-t-butyl ester
EINECS	Contact for details

Quality Control

Every batch of Bromo-Peg4-Ch2Cootbu is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity specifications suitable for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay (HPLC), identity (NMR, IR), and impurity profiles. We support cGMP manufacturing for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.