Description

Propargyl-Peg2-T-Butyl Ester is a specialized bifunctional chemical building block featuring both a propargyl group and a protected carboxylic acid. This compound is essential for advanced organic synthesis, particularly in click chemistry and bioconjugation strategies, enabling the precise construction of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel drug candidates, diagnostic probes, and functional polymers.

Application

• Key intermediate in click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Building block for the synthesis of PEGylated linkers and spacers used in bioconjugation and drug delivery systems.
• Precursor for functionalizing surfaces, nanoparticles, and polymers with alkyne handles for subsequent modification.
• Used in the research and development of ADC (Antibody-Drug Conjugate) payloads and linkers.
• Intermediate in the preparation of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Chemical tool for material science applications, including the creation of smart hydrogels and functional coatings.

Basic Information

Product Name	Propargyl-Peg2-T-Butyl Ester
CAS No.	1807503-80-5
Molecular Formula	C14H24O5
Molecular Weight	272.34 g/mol
Synonyms	2-[2-(2-Prop-2-ynoxyethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-prop-2-yn-1-yloxyethoxy)ethoxy]acetate; Propargyl-PEG2-t-butyl ester; Propargyl-PEG2-OtBu ester; Alkyne-PEG2-t-butyl ester; t-Butyl-PEG2-propargyl ether; 2,5,8-Trioxa-11-dodecyn-1-oic acid, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your research and cGMP-compliant manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.