Description

Endo-Bcn-Peg4-Nhs Ester is a heterobifunctional crosslinker featuring an endo-BCN group and an amine-reactive NHS ester, connected by a tetraethylene glycol spacer. This compound is specifically engineered for bioorthogonal click chemistry applications, enabling efficient and selective conjugation under mild, aqueous conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, proteomics, and ADC (Antibody-Drug Conjugate) development, facilitating the precise labeling and modification of biomolecules.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of antibodies, proteins, and peptides via amine groups for imaging, diagnostics, and therapeutic applications.
• ADC (Antibody-Drug Conjugate) Development: Critical linker component for attaching cytotoxic payloads to monoclonal antibodies through strain-promoted azide-alkyne cycloaddition (SPAAC) chemistry.
• Surface Functionalization: Immobilization of biomolecules onto nanoparticles, biosensors, and microarray surfaces for assay development.
• Polymer and Material Science: Synthesis of functionalized polymers and hydrogels with bioactive properties for drug delivery and tissue engineering.
• Chemical Biology and Proteomics: Tool for studying protein-protein interactions, cellular pathways, and post-translational modifications.
• Diagnostic Reagent Synthesis: Production of fluorescent, enzymatic, or radioactive probes for in vitro and in vivo diagnostics.

Basic Information

Product Name	Endo-Bcn-Peg4-Nhs Ester
CAS No.	1807501-86-5
Molecular Formula	C31H48N4O11
Molecular Weight	652.7 g/mol
Synonyms	endo-BCN-PEG4-NHS ester; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-oxo-2,5,8,11-tetraoxatetradecan-14-yl) (2,5-dioxopyrrolidin-1-yl) carbonate; BCN-PEG4-NHS Ester; endo-BCN-PEG4-NHS; BCN-PEG4-NHS Ester; BCN-(PEG)4-NHS; BCN-PEG4-NHS Crosslinker; BCN-PEG4-SCM
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg4-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.