Description

Ethyl (S)-Pyrrolidine-3-Carboxylate is a high-value chiral building block and intermediate of significant importance in modern synthetic chemistry. Its primary value lies in its stereochemically defined pyrrolidine scaffold, which is a privileged structure in medicinal chemistry for constructing bioactive molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals requiring precise three-dimensional architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and enzyme inhibitors.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in asymmetric catalytic reactions to introduce stereogenic centers with high enantiomeric purity.
• Proline Derivative Synthesis: Serves as a protected ester form of (S)-3-substituted proline derivatives, which are valuable in peptide mimetics and organocatalysis.
• Agrochemical Research: Intermediate in the development of advanced herbicides, fungicides, and plant growth regulators with specific chiral activity.
• Ligand and Catalyst Development: Building block for creating novel chiral ligands used in transition metal catalysis for fine chemical production.
• Academic and R&D: Critical material for methodological development in organic synthesis and medicinal chemistry research within university and corporate laboratories.

Basic Information

Product Name	Ethyl (S)-Pyrrolidine-3-Carboxylate
CAS No.	1807380-84-2
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(S)-Ethyl Pyrrolidine-3-Carboxylate; (S)-1-Azabicyclo[3.1.0]hexane-3-carboxylic Acid Ethyl Ester (related bicyclic form); Ethyl (3S)-Pyrrolidine-3-Carboxylate; (S)-3-(Ethoxycarbonyl)pyrrolidine; (S)-Pyrrolidine-3-carboxylic Acid Ethyl Ester; (3S)-Pyrrolidine-3-carboxylic Acid Ethyl Ester; L-Proline Ethyl Ester Derivative; SCHEMBL23883031
EINECS	Contact for details

Quality Control

Our Ethyl (S)-Pyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. Certificates of Analysis (COA) detailing purity, identity, and chiral purity are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.