Description

Ethyl 4-Bromo-5-Fluoro-2-Methylbenzoate is a high-purity, multi-functional benzoate ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the strategic placement of bromo and fluoro substituents on the aromatic ring, which are essential for introducing key pharmacophores and modifying electronic properties in target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex organic materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the halogenated aromatic core contributes to biological activity and environmental stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and specialty polymers, leveraging its halogenated structure to fine-tune material properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, enabling the construction of complex biaryl systems.
• Fluorine Chemistry: The presence of the fluorine atom makes it a valuable synthon for introducing fluorine into molecules to enhance metabolic stability, bioavailability, and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	Ethyl 4-Bromo-5-Fluoro-2-Methylbenzoate
CAS No.	1807043-81-7
Molecular Formula	C10H10BrFO2
Molecular Weight	261.09 g/mol
Synonyms	Ethyl 4-bromo-5-fluoro-2-methylbenzoate; 4-Bromo-5-fluoro-2-methylbenzoic acid ethyl ester; Benzoic acid, 4-bromo-5-fluoro-2-methyl-, ethyl ester; 2-Methyl-4-bromo-5-fluorobenzoic acid ethyl ester; 1807043-81-7; Ethyl 4-bromo-5-fluoro-o-toluate
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-5-Fluoro-2-Methylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.