Description

Methyl 4-Amino-5-(Trifluoromethyl)Pyridine-2-Carboxylate is a high-value trifluoromethylated pyridine derivative, a key building block in modern synthetic chemistry. Its structure, featuring both an amino and an ester functional group, makes it a versatile intermediate for constructing complex molecules with enhanced biological activity and physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Acts as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its multiple reactive sites.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	Methyl 4-Amino-5-(Trifluoromethyl)Pyridine-2-Carboxylate
CAS No.	1806983-37-8
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	Methyl 4-amino-5-(trifluoromethyl)picolinate; 4-Amino-5-(trifluoromethyl)picolinic acid methyl ester; 2-Pyridinecarboxylic acid, 4-amino-5-(trifluoromethyl)-, methyl ester; 5-(Trifluoromethyl)-4-aminopicolinic acid methyl ester; Methyl 4-amino-5-trifluoromethylpyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-Amino-5-(Trifluoromethyl)Pyridine-2-Carboxylate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.