Description

2-Bromo-6-Fluoropyridine-3-Carbonitrile is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitrile substituents, makes it an exceptionally versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for developing kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core for bioactivity.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form complex biaryl structures.
• Nucleophilic Substitution: The fluorine atom can be selectively displaced, allowing for further functionalization and diversification of the pyridine ring.
• Cyanohydrin & Amide Formation: The nitrile group can be hydrolyzed to carboxylic acids or reduced to amines, providing additional handles for molecular elaboration.

Basic Information

Product Name	2-Bromo-6-Fluoropyridine-3-Carbonitrile
CAS No.	1806849-41-1
Molecular Formula	C6H2BrFN2
Molecular Weight	200.99 g/mol
Synonyms	3-Cyano-2-bromo-6-fluoropyridine; 6-Fluoro-2-bromopyridine-3-carbonitrile; 2-Bromo-6-fluoro-3-pyridinecarbonitrile; 2-Bromo-6-fluoronicotinonitrile; 1806849-41-1; 2-Br-6-F-3-CN-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-Fluoropyridine-3-Carbonitrile is manufactured and tested under strict quality management protocols to ensure consistency and purity for research and scale-up applications. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with comprehensive identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We support custom synthesis and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to direct light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.