Description

Pyridine, 4-Bromo-2-(Difluoromethyl)-3-Methyl- is a specialized halogenated pyridine derivative, a high-value building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines bromine and difluoromethyl substituents on the pyridine ring, enabling precise modifications in complex molecule construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the creation of functionalized organic materials, including liquid crystals and organic semiconductors, due to its electron-deficient pyridine core and halogen handles.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	Pyridine, 4-Bromo-2-(Difluoromethyl)-3-Methyl-
CAS No.	1806777-93-4
Molecular Formula	C8H6BrF2N
Molecular Weight	234.04 g/mol
Synonyms	4-Bromo-2-(difluoromethyl)-3-methylpyridine; 3-Methyl-4-bromo-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)-3-methyl-4-bromopyridine; 4-Bromo-3-methyl-2-(difluoromethyl)pyridine; 1806777-93-4; Pyridine, 4-bromo-2-(difluoromethyl)-3-methyl-
EINECS	Contact for details

Quality Control

Our Pyridine, 4-Bromo-2-(Difluoromethyl)-3-Methyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen or argon after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/GC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC/GC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.