Description

6-(Difluoromethyl)-5-Methylpyridin-3-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluoromethylated pyridine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating new drug candidates and specialty molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small-molecule drugs, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and insecticides, leveraging the biological activity of the difluoromethyl group.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, fluorinated organic compounds for various high-value applications.
• Ligand & Catalyst Development: Potential use in creating specialized ligands for catalysis or as a precursor for metal-organic frameworks (MOFs).

Basic Information

Product Name	6-(Difluoromethyl)-5-Methylpyridin-3-Amine
CAS No.	1806766-70-0
Molecular Formula	C7H8F2N2
Molecular Weight	158.15 g/mol
Synonyms	5-Methyl-6-(difluoromethyl)pyridin-3-amine; 3-Amino-5-methyl-6-(difluoromethyl)pyridine; 6-(Difluoromethyl)-5-methyl-3-pyridinamine; 5-Methyl-6-difluoromethyl-pyridin-3-ylamine; 1806766-70-0; 5-Methyl-6-(difluoromethyl)-3-pyridinamine
EINECS	Contact for details

Quality Control

Every batch of 6-(Difluoromethyl)-5-Methylpyridin-3-Amine is produced under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets typical research and development requirements, with comprehensive Certificates of Analysis (COA) provided for each shipment. We adhere to cGMP principles for pharmaceutical intermediates and can support custom synthesis to meet specific client specifications and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.