Description

2(1H)-Pyridinone, 3-(Difluoromethyl)- is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for introducing the unique difluoromethylpyridinone pharmacophore into target molecules, which can modulate physicochemical and metabolic properties. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the difluoromethyl-substituted pyridinone core.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a component in linker or warhead design for targeted protein degradation platforms.
• Material Science Research: Investigated as a monomer or functional additive for creating polymers with specific electronic or surface properties.
• Ligand Development for Catalysis: Employed in the synthesis of novel nitrogen-containing ligands for transition metal catalysis.
• Fluorine Chemistry Studies: A valuable substrate for exploring the reactivity and effects of the difluoromethyl group in heteroaromatic systems.

Basic Information

Item	Detail
Product Name	2(1H)-Pyridinone, 3-(Difluoromethyl)-
CAS No.	1806766-03-9
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	3-(Difluoromethyl)-1H-pyridin-2-one; 3-(Difluoromethyl)-2(1H)-pyridinone; 3-(Difluoromethyl)pyridin-2(1H)-one; 3-Difluoromethyl-1H-pyridin-2-one; 3-Difluoromethyl-2-hydroxypyridine; 2-Hydroxy-3-(difluoromethyl)pyridine; 1806766-03-9
EINECS	Contact for details

Quality Control

Our 2(1H)-Pyridinone, 3-(Difluoromethyl)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, impurities, and full characterization data are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.