Description

Methyl 3-Bromo-5-Fluoro-2-Nitrobenzoate is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. This compound matters because its unique combination of bromo, fluoro, and nitro substituents on a benzoate ester scaffold provides versatile reactivity for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and pesticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials where its specific substitution pattern can tune material properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups allow for selective displacement reactions, enabling further functionalization of the aromatic ring.
• Chemical Library Synthesis: A valuable building block for combinatorial and parallel synthesis in drug discovery to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	Methyl 3-Bromo-5-Fluoro-2-Nitrobenzoate
CAS No.	1805504-03-3
Molecular Formula	C8H5BrFNO4
Molecular Weight	278.03 g/mol
Synonyms	3-Bromo-5-fluoro-2-nitrobenzoic acid methyl ester; Methyl 3-bromo-5-fluoro-2-nitrobenzoate; Benzoic acid, 3-bromo-5-fluoro-2-nitro-, methyl ester; 2-Nitro-3-bromo-5-fluorobenzoic acid methyl ester; Methyl ester of 3-bromo-5-fluoro-2-nitrobenzoic acid
EINECS	Contact for details

Quality Control

Our Methyl 3-Bromo-5-Fluoro-2-Nitrobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.