Description

4-Amino-6-(Trifluoromethyl)Pyridine-3-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its amino and nitrile functional groups on a trifluoromethylated pyridine core. This compound is essential for medicinal chemistry and agrochemical research, where its unique structure enables the synthesis of novel active ingredients with enhanced properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Chemical Biology Probes: Useful for designing molecular probes and tags due to its reactive amino and nitrile handles.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	4-Amino-6-(Trifluoromethyl)Pyridine-3-Carbonitrile
CAS No.	1805396-59-1
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	4-Amino-6-(trifluoromethyl)nicotinonitrile; 3-Cyano-6-(trifluoromethyl)pyridin-4-amine; 4-Amino-6-trifluoromethylpyridine-3-carbonitrile; 6-(Trifluoromethyl)-4-aminopyridine-3-carbonitrile; 4-Amino-6-(trifluoromethyl)-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 4-amino-6-(trifluoromethyl)-; 4-Amino-6-(trifluoromethyl)-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 4-Amino-6-(Trifluoromethyl)Pyridine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.