Description

2-Bromo-3-(difluoromethyl)-5-methylpyridine is a high-value, multi-functional pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique halogenated and fluorinated structure makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the difluoromethyl group to enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry: A valuable scaffold for introducing fluorine atoms into target molecules, a common strategy in medicinal chemistry to modulate lipophilicity and binding affinity.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2-Bromo-3-(difluoromethyl)-5-methylpyridine
CAS No.	1805314-75-3
Molecular Formula	C7H6BrF2N
Molecular Weight	222.03 g/mol
Synonyms	3-(Difluoromethyl)-5-methyl-2-bromopyridine; 2-Bromo-3-difluoromethyl-5-methylpyridine; 5-Methyl-2-bromo-3-(difluoromethyl)pyridine; Pyridine, 2-bromo-3-(difluoromethyl)-5-methyl-; 1805314-75-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-(difluoromethyl)-5-methylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming the product meets your specified requirements. Our quality commitment supports applications in cGMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.